Protein Details: Amiloride-sensitive sodium channel subunit beta
Protein ID
ICDB_Pro_0513
Protein Name
Amiloride-sensitive sodium channel subunit beta
Gene Name
Scnn1b
Organism
Rattus norvegicus (Rat)
Length
638 amino acids
AlphaFoldDB
AF-P37090-F1-model_v4.pdb
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water; which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis; but also in airway surface liquid homeostasis; which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney; colon; lung and sweat glands. Also plays a role in taste perception.
Sequence
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Expressed in lung and epididymis. In the caput region of the epididymis; expressed at the luminal and basolateral surfaces of the ducts and in the smooth muscle coat. In the caudal region of the epididymis; expressed along the luminal border but not continuously; in the smooth muscle coat; in the interstitial muscle tissue and in sperm in the caudal lumen. In the caudal region of the epididymis; expressed along the luminal border but not continuously; in the smooth muscle coat; in the interstitial muscle tissue and in sperm in the caudal lumen. In the caudal region of the epididymis; expressed along the luminal border but not continuously; in the smooth muscle coat; in the interstitial muscle tissue and in sperm in the caudal lumen.
DOI ID
10.1038/367463a0; 10.1161/01.hyp.29.1.131; 10.1093/emboj/16.5.899; 10.1073/pnas.95.6.3301; 10.1152/ajprenal.2001.280.6.f1093; 10.1074/jbc.m110904200; 10.1074/jbc.m211153200; 10.1007/s10735-019-09813-3; 10.1038/87562
RefSeq
NP_036780.1